How does bacterial growth environment affect antibiotic efficacy and the evolution of resistance?
Many experiments on bacterial action and the evolution of resistance are done in standardised lab conditions, yet bacteria in infections experience complex growth conditions, which can vary in time and space. Exposure to nutrients can also vary between different infections. We have investigated how the richness of the nutrient medium affects the efficacy of action of ribosome-targeting antibiotics. We find apparently conflicting results: some ribosome targeting antibiotics work better on rich media while others work better on poor media. These results can be explained by a simple mathematical model. I will also describe theoretical and preliminary experimental work on the effect of spatial gradients of antibiotic on the evolution of resistance.
Rosalind is a Royal Society University Research Fellow and Reader in Biological Physics at the School of Physics and Astronomy, Edinburgh University.
Her research focuses on biological and soft condensed matter physics, using simulations, theory and experiments. In particular, she is interested in microbe-environment interactions - how single-celled organisms such as bacteria survive and grow in complex and changing environments.
Who should attend?
Lecture Theatre 6 (E-Floor)
Sheffield S3 7RH
For venue map and directions please click here.